Degenerative Myelopathy (DM)
Degenerative myelopathy (DM) is a progressive neurodegenerative disease that occurs in many breeds of dog. The test we offer is based on the research done at the University of Missouri which identified mutations in the SOD1-A gene. To date, the major mutation associated with this disease has been detected in 124 breeds, with a second mutation, SOD1-B limited to the Bernese Mountain Dog. The test for this second mutation is DM-exon1.
The disease is an adult-onset condition that has ALS like symptoms: progressive limb weakness and muscle loss, tremors, difficulty rising, and stumbling. Affected animals develop spinal and hind end problems later in life. It is inherited as a recessive disease based on these mutations, but there is also ongoing work to determine other factors that may play a role in severity and age of onset.
CMO- Craniomandibular Osteopathy
CMO is a bone disease that affects young dogs in several breeds, but most notably West Highland White and Scottish.Terriers. Affected dogs may exhibit a variety of symptoms including pain, periodic fever, difficulty opening the mouth and growth of bony lesions primarily on cranial bones. In 2015, researchers at the University of Bern and the University of Helsinki described a mutation associated with this disease in three terrier breeds. The disease appears to be inherited as an autosomal dominant mutation with incomplete penetrance. Most affected animals have two copies of the mutation but some have only a single copy. This appears to be somewhat breed dependent as all of the Scottish and Cairn Terriers that had two copies were diagnosed with CMO. In West Highland Whites, where the mutation is most common (40% have one copy), about half of the dogs with two copies were diagnosed with CMO. Scotties and Westies with one copy were diagnosed with CMO at rates of 7% and 3.5%, respectively.
Chondrodystophy and Intervertabral Disc Degeneration (CDDY and IVDD risk)
Our testing provides results for two related mutations that affect both the health and stature of many breeds of dog. Both mutations are FGF4 retrogenes, which are essentially portions of the true FGF4 gene which have been inserted into other parts of the genome.
The CDPA retrogene was first described in 2009 and was shown to be the cause of the short legs found in many, many breeds (Daschunds, Basset Hound, French Bulldog, etc.).
This mutation is dominant. Either one or two copies of the mutation result in the same short-legged phenotype. In many breeds all animals have two copies of this mutation.
A second FGF4 retrogene (CDDY) was discovered and described by the Bannasch lab in 2017 that shows an effect on both leg length and more importantly an association with premature spinal disc degeneration (IVDD). IVDD is found in many short-legged breeds and is a painful disease with a relatively high mortality rate. This mutation shows a dominant mode of inheritance with respect to IVDD. Dogs with either one or two copies of the CDDY insertion are predisposed to IVDD. With respect to leg length, the mode of inheritance is semi-dominant. Within a given breed, dogs with one copy will have shorter legs than dogs with zero copies and dogs with two copies will have even shorter legs.
vWD Type III
Type III von Willebrand Disease (vWD) is a very severe form of the disease in which affected animals do not produce any von Willebrand Factor protein in their blood. This condition makes them more likely to bleed abnormally and severely. This can lead to life threatening consequences in situations such as accidental injuries, spaying, or neutering. Because it is an autosomal recessive disorder, Shetland Sheepdogs, Scottish Terriers and Kooikerhondje that are "Carriers" of the disease show no signs of vWD, yet can pass the gene along and perpetuate the disease through breeding. Without testing, the potential result is more affected animals.
Although there is a significant frequency of vWD in Shelties and Scotties, no effective treatments exist. Responsible breeders have attempted to use factor assay, protein-based tests for vWD but have been unsuccessful in reducing the frequency of the disease. There are simply too many variables, such as estrus and thyroid function which produce variation in test results, making these approaches less than ideal. Therefore, breeders have heretofore been unable to combat the disease by using responsible breeding strategies to reduce the incidence of vWD in future generations of dogs.
Based on research conducted at Michigan State University and the University of Michigan leading to the discovery of the mutations causing vWD in both Shetland Sheepdogs and Scottish Terriers, VetGen is proud to exclusively offer a non-invasive, highly reliable DNA-based test to detect mutated vWD genes. This test provides breeders and owners a definitive answer as to whether an animal is an "Affected", "Carrier", or "Clear". With this information in hand, breeders and owners have key insight into their bloodstock and can proceed to make informed decisions about training, showing, and breeding plans for each dog.
By following the simple instructions provided in VetGen's DNA Sample Collection Kit, dog owners and breeders collect DNA samples using a soft cheek brush. By gently brushing the inside of the dog's cheek, cells containing DNA are removed. It is this DNA sample that VetGen analyzes to determine the genetic status of each dog. As soon as VetGen receives the completed DNA Sample Collection Kit, >the DNA samples are processed and a diagnosis is formed. Within two to four weeks, this diagnosis is provided to the customer in a summary report.
I have had both my breeding dogs tested and they are clear of
CMO, DM-SOD1, vWD, CCPA/CCPA CDDY and the Patellars.
Parents are registered with the OFA and also have Chic numbers
Bred with H.E.A.R.T Program
Available to go to forever homes after 9 to 10 weeks.
Puppies will be $2200.00 Limited Registration
Please Note that most of my puppies are wheaten or brindle
Puppies come with
Vet Checked at lease twice
Copies of both parents Pedigrees
Copies of both parents health test.
Blanket for your puppy with mom's smell
Small bag and can of Royal Canin
2 Year Health Guarantee if kept on Nuvet Plus
Vetgen/Embarkvet tested, OFA with Chic number
BRED with Heart AKC on all Scottish Terrier Pups
List of things you needed for your puppy
Collar, Holter & Leash
Food and NuVet vitamins
Food and water bowls
Scottish Terrier Puppies
Chandler AZ 85224 US
Copyright Diane Crosman. All Rights Reserved. Scottish Terrier Puppies AKC Scottie Pups